Hunger Hormones: What is Leptin and Leptin Resistance

  • By: kim
  • Date: June 27, 2021
  • Time to read: 4 min.

If you have struggled with controlling your weight it may be that you are leptin resistant. Here is an article that explores what the hormone leptin is and it’s role in weight control.

What Is the Hormone Leptin?

Leptin is a protein comprised of 167 amino acids. The word Leptin originates from the Greek word “Leptos” which translates to “thin.” Leptin plays a huge role within the body in regards to hunger and appetite. It is also essential in behavior, metabolism, and energy expenditure and intake, making it one of the most vital hormones derived from adipose tissue.

Leptin has been given credit as the first fat cell-derived hormone to be discovered.

What Does Leptin Do?

In simple terms leptin is the hormone that says ‘stop eating I’m full’. This hormone acts on the brain and is connected with body weight and the regulating of food intake.

Fat tissue within the body is responsible for producing the Leptin hormone. Since it is secreted by fat cells, it would be easy to assume that the more obese a person is, the more leptin they have available to tell their body they are full. You would also assume that their weight would normalize once again.

This is a wonderful theory; however, when dealing with damaged endocrine and metabolism pathways, it becomes more involved. The leptin is there it just isn’t doing what it should.

Leptin is the hormone that produces a feeling of satiety or fullness and signals the body when it has eaten enough food. When functioning optimally, this hormone may make it easier to resist the temptation to eating high calorie foods.

Leptin circulates within the bloodstream, relaying messages to the brain regarding energy storage. This is how it operates in regulating metabolism and appetite.

A percentage of people suffer severe obesity due to a leptin hormone imbalance. Due to the problem, they continually want to consume more and more food. There have been numerous studies and trials for treating the imbalance and therefore the obesity problem. The people who were the most overweight were treated. They did show some signs of weight loss. However the results from the studies have been inconclusive and are continuing.

Studies show that due to the poor solubility, low potency and low circulating half-life of leptin, frequent and large doses are needed.

Leptin Resistance

Leptin is linked directly to insulin levels. Leptin resistance is a condition experienced by many people today. The body perceives leptin resistance as starvation. This ends up activating multiple mechanisms to increase fat stores as opposed to burning excess fat stores.

The body releases leptin as it should but the brain does not respond to the leptin trigger as it should. Simply put, the brain does not realize the stomach is full so appetite is not suppressed. This condition is characterized by obesity, blood-sugar issues, high blood pressure, stroke and heart disease.

Elevated leptin levels experienced with leptin resistance may also age you faster than normal, decrease fertility and be a contributing factor to obesity. Signs of leptin resistance can include having difficulty sticking to changes in your health regime and difficulty in improving a health issue or losing weight.

Leptin resistance is a complex situation involving the endocrine system. The good news is that you can make lasting changes; however, it is going to require more than will power and counting your calories. Many obese individuals have endocrine issues or a damaged metabolism which needs to be addressed by medical professionals.

Further Reading and Resources

The Famous Jack Kruse Leptin Reset Prescription

Jack Kruse is definitely onto something with this leptin reset prescription. I have tried to follow his protocol for a couple of years with I have to admit various degrees of compliance and it has all been positive. I have experienced weight loss, increasing energy and a more positive attitude to life.

Leptin Prescription by Jack Kruse

1.  First make sure you really are Leptin resistant (LR) to begin with.

The easiest way to do this if you are heavy is to look in the mirror.  If you’re overweight you definitely are Leptin resistant.  If you still have a large appetite and crave carbohydrates, especially at night, these are also signs that you are likely Leptin resistant…… read more

Leptin Low Carb Diet and Hunger

Leptin is a hormone made by fat cells. When there are a lot of fat cells they secrete a lot of leptin. What does leptin do? It seems that every day a new function for leptin is postulated, but for our purposes now, let’s stick with what most scientists consider the primary function of leptin: regulation of the fat mass by regulating hunger…. read more

Circumventing Leptin Resistance for Weight Control

Leptin, an adipocyte-derived hormone normally transported across the blood brain barrier (BBB), was initially heralded as a major negative feedback signal relaying information of the body’s energy stores to these hypothalamic networks on a moment to moment basis to maintain body weight around a set point. However, results of numerous investigations in rodents and humans have been disappointing because circulating leptin levels display marked variations among individuals and rise in direct proportion to the age-related increase in adipose tissue depots. Thus, leptin concentrations are greatly elevated in obese subjects… read more

what is leptin




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